Let be the static potential and the drag coefficient, so terminal Genetic drift under force is . The probability current is only after imposing the desired relation; instead start independently from . At thermal equilibrium and detailed balance requires . Substitution yields
At 298 K with m, this gives approximately m s. The argument assumes an overdamped particle in an equilibrium thermal bath, rather than arbitrary driven diffusion.
The stationary occupation ratio is . Balance of the two probability currents gives , and Boltzmann occupation of the trapped macrostates gives . Therefore
The sketch has two wells separated by 1 micrometre, with the second free-energy level higher by and an intervening escape barrier. Free energy includes the volume of each trapped basin; equal minimum potential heights alone would not ensure equal occupations if basin shapes differed.
Figure 1.
Two-state free-energy tilt and the distinct fast and slow timescales of a carbon-pulse response
. Details.