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Incoming links: Protein–DNA interaction
Protein–DNA interaction Created 2026-10-20 Updated 2026-11-05
A protein–DNA interaction is physical association between a protein and DNA. Contacts can depend on base sequence, DNA shape, charge or interactions with other bound factors. A transcription factor can recognize selected regulatory sites, while histones package much larger fractions of the genome. Detecting association establishes contact or proximity under the assay conditions; regulation, bending or bridging requires additional functional or structural evidence. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapter 7, DNA-Binding Motifs in Gene Regulatory Proteins