The quantum conditional entropy is . Unlike its classical counterpart, it may be negative.
For a bipartite pure state with finite Von Neumann entropy, the joint Von Neumann entropy is zero, so its quantum conditional entropy is . The Schmidt decomposition makes the nonzero eigenvalues of the squared Schmidt coefficients. Their Shannon entropy vanishes exactly when there is one coefficient, equivalently the joint pure state is a product state. Thus negative quantum conditional entropy detects exactly the entangled bipartite pure states; it is only a sufficient criterion for entanglement of general mixed density operators.
For bipartite density operators,
This is a consequence of Strong subadditivity of Von Neumann entropy.
If and , then
The proof couples the two states through their positive and negative differences, then combines concavity of quantum conditional entropy with the entropy bound for a binary mixture.
For every state on ,
The upper bound follows from Subadditivity of Von Neumann entropy and the lower bound from the Araki–Lieb inequality.

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