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For woman $i$, write $m_i$ for the number of births, $Y_i$ for the number with defects, $a_i$ for baseline age, and $e_i$ for exposure. Let $p_i$ be the common marginal defect probability for her births. The first fit is a grouped grouped-binomial logistic regression:It assumes independent women and, conditionally on their covariates, independent births with the same probability within each woman. The supplied birth totals are the binomial denominators; fitting the proportions with weights $m_i$ is equivalent to this grouped-binomial specification. The fitted linear predictor is $-1.74272+0.02030a_i+2.33028e_i$.

The second fit is a generalized additive model with the same logit link function and the mean specificationThe functions $f_a,f_e$ are penalized cubic regression splines with natural boundary conditions. Centering constraints such as ${\sum }_i{f}_a(a_i)={\sum }_i{f}_e(e_i)=0$ separate them from the intercept; the fitted centered intercept is $-0.2031$. Their second derivative roughness penalties control complexity.

The call estimates a common scale rather than fixing it at one. Its working variance specification for the counts isEquivalently the variance of $Y_i/m_i$ is $\varphi p_i(1-p_i)/m_i$. This is the working moment interpretation of an overdispersed binomial generalized additive model: the code uses binomial deviance for fitting and estimated scale for inference. With $\varphi \ne 1$, it is not an exact independent-binomial sampling model. Women are still treated as independent groups, but within-woman dependence or unobserved heterogeneity can motivate the extra dispersion. The quasibinomial regression interpretation states what the scaled analysis assumes without inventing a full probability distribution for its counts.

The original PDF's age smooth is nearly flat, its uncertainty band includes zero across the age range, and its approximate p-value is $0.859$. The exposure smooth is increasing and convex: it is fairly flat at low exposure and rises more steeply at high exposure. Its effective degrees of freedom $1.895$ suggest a modest departure from a straight line, rather than a highly oscillatory relationship.

A suitable simpler model is therefore the grouped quasibinomial regressionwith age omitted and dispersion estimated. A positive quadratic coefficient captures the convex exposure relationship; retaining the linear term respects the usual polynomial hierarchy. This model should be refitted, rather than assigning coefficients from the smooth plot. Compare its residual pattern and dispersion-adjusted fit with the additive model to check that the quadratic approximation is adequate. An exposure-only quadratic logit model is a justified parsimonious candidate, while the graph does not justify a sharp threshold or a zero-dispersion model.

The quasibinomial regression retains the logit link and mean function $p_i=(1+e^{-x_i^T\beta }{)}^{-1}$ but uses the working variance function $\mathrm{Var}(Y_i)=\varphi p_i(1-p_i)$. Its quasi-score equation isso multiplying by the common dispersion parameter does not change the coefficient estimates. Iteratively reweighted least squares therefore gives the same fitted means and coefficients as the binomial model. The usual Pearson dispersion estimator isThe estimated coefficient covariance matrix is $\hat{\varphi }(X^{T}WX{)}^{-1}$, with $W_{ii}={\hat{p}}_i(1-{\hat{p}}_i)$. From the intercept standard errors, $(1.08921/1.13031{)}^2\simeq 0.92860$; the rounded slope errors give approximately the same factor. The display uses approximate Student's t-tests with 118 residual degrees of freedom instead of fixed-dispersion normal tests.

For a genuinely individual binary response, the Bernoulli distribution identity $Y_i^2=Y_i$ forces $\mathrm{Var}(Y_i)=p_i(1-p_i)$. Thus $\varphi \ne 1$ is a working quasi-likelihood specification, not a different independent binary distribution with that mean. The mild estimated underdispersion does not establish an improved model, and the mean predictions are unchanged. In particular, a scalar rescaling does not model correlation among users, and usual likelihood-based Akaike information criterion comparisons are unavailable for a family without a specified probability likelihood. The output gives no convincing reason to prefer model3 to model2.