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Nuclear engineering designs and studies systems that use nuclear reactions or manage materials with radioactivity. Its subjects include nuclear reactors, radiation detection, radiation shielding, nuclear fuel, the behaviour of structural materials under irradiation, and radioactive waste management.

A nuclear power plant shows why several areas of engineering must work together. Nuclear fission releases energy; a coolant transports the resulting heat; a heat engine converts part of that heat to mechanical work; an electrical generator produces electrical energy. In a pressurized water reactor, a heat exchanger transfers heat from the pressurized reactor coolant to a separate circuit that produces steam. Thus neutron physics, heat transfer, fluid mechanics and materials science constrain the same design.^[ref]

Radiation detection makes interactions of ionizing radiation with matter into observable signals. An ionization chamber collects charge created in a gas; a scintillation detector converts deposited energy into light; a semiconductor detector measures charge carriers created in a solid. The instrument detects interactions, so its response depends on radiation type, energy and geometry.

For an ideal counting model, expected detected events satisfy $N=\epsilon Rt$, where $R$ is the relevant incident event rate, $t$ is observation time and $\epsilon$ is detection efficiency. Background adds counts, while dead time can lose them. Estimating a source's radioactive activity therefore requires calibration and a model of emissions and transport, rather than equating the displayed count rate with decay rate.