A Rayleigh interferometer compares optical paths through a sample and a reference. A path-length difference shifts the interference phase by . In analytical ultracentrifugation, sample and reference sectors produce concentration-dependent fringe shifts, allowing radial concentration scans without requiring the solute to absorb at the probe wavelength.[ref]
Optical Systems Used for AUC by Beckman Coulter Life Sciences. Rayleigh interference optics: reference sector, refractive-index difference and fringe displacement
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