A sensitivity coefficient describes how an estimated output of a measurement model changes when one input changes slightly. For , the first-order coefficients, evaluated at the input estimates, are
A sensitivity coefficient can have a sign and a unit of measurement: for an output in ohms and an input in volts, its unit is ohms per volt. The GUM also describes estimating sensitivity coefficients experimentally by varying inputs.[ref]
In a measurement uncertainty budget, propagation of uncertainty uses these coefficients to transform input variances and covariances:
Here denotes an input standard uncertainty. The derivative's sign disappears from its independent variance term but still matters in a covariance term.[ref]
For an original electrical resistance example, , and give and
Independent input standard uncertainties of0.1volt and0.02ampere each contribute0.05ohm on the output scale, giving . A larger sensitivity coefficient alone does not identify the dominant uncertainty: the input standard uncertainty and any correlations also matter.
The derivative is a local approximation. If the input spread spans a strongly nonlinear part of the measurement model, first-order propagation of uncertainty can be inadequate even when every derivative has been computed correctly.

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