A receptor responding to serotonin. Subtypes differ in signalling and distribution, so increasing transmitter availability can affect several mechanisms at once.
A serotonin receptor subtype implicated in particular local circuits, including some threat-related extended-amygdala pathways.
It is a G protein-coupled receptor commonly linked to Gq-family signalling. Its contribution to behaviour depends on which cells express it and which local circuit receives the signal; receptor identity alone does not predict one universal behavioural effect. [ref]
A serotonin receptor that can act as a raphe autoreceptor or a receptor on non-serotonergic target cells. Developmental and acute functions must be distinguished.

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  1. Receptor (biochemistry)
  2. Protein
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