For a fibration with suitable connectivity, the cohomological Serre spectral sequence has
with differential .
For a Serre fibration, this first-quadrant spectral sequence has differential of bidegree and a fiber-cohomology local coefficient system on the base. A simply connected base makes that system constant. Its edge map is restriction to the fiber; a surviving fiber class is the restriction of a total-space class. For commutative ring coefficients it is multiplicative and its differentials are graded derivations.
There is no fiber bundle when and is odd. A local trivialization makes a retract of an open subset of , so for ; the long exact sequence of homotopy groups of a fibration makes connected. In the multiplicative rational Serre spectral sequence, only base columns zero and occur. Since , a fibre class must satisfy , the base generator. Its degree is even. If is its first vanishing power, the derivation law gives on the page, a contradiction. Bounded fibre cohomology ensures such a vanishing power exists. In particular cannot be the total space of a bundle over .
A Serre fibration is a map having the homotopy lifting property with respect to every disc, equivalently every CW complex.
For a based Serre fibration with fibre over the basepoint, lift a based cube in from its constant bottom face, keeping the side faces fixed. Its final face lies in , giving surjectivity of the relative map. Homotopies in lift; two lifts of the same cube are relatively homotopic by lifting with both side liftings prescribed. This gives injectivity. For this is a group isomorphism; at it is initially a bijection of pointed sets, unless the relative set is endowed with the group law transported through the fibration.
For a Serre fibration over , cover the base by a contractible punctured sphere and a contractible ball. Excision relative to the preimage of the punctured sphere identifies the relative pair with the product of and up to homotopy. The base pair has a single free homology group in degree , so the Künneth theorem gives the displayed shift without a torsion term. The relative long exact sequence then gives . The connecting map retains the twisting of the original Serre fibration.
For a Serre fibration with this fiber over a simply connected CW base, the fiber identity class has only one possible nonzero outgoing differential in the cohomological Serre spectral sequence, landing in . If that group vanishes, the class extends to the CW total space. Its representing map, paired with projection to , is an isomorphism on fiber and base homotopy groups and hence a weak homotopy equivalence to the product.
For a map , let consist of points of and paths starting at their images, with projection . Appending segments of a base homotopy proves the homotopy lifting property, so is a Serre fibration. The constant-path inclusion satisfies and is a homotopy equivalence: forget the path for an inverse, and shorten paths to prove the homotopy. The homotopy need not preserve the endpoint in , so the statement concerns an equivalence of total spaces over a commuting triangle, not a fibrewise inverse. The fibre over is the homotopy fibre of .
A map has the homotopy lifting property with respect to when every homotopy whose initial map lifts to has a lift extending that initial lift.
For a based fibration , lifting representatives defines connecting maps and an exact sequence
For a fibration over , the only possible differential in the homological Serre spectral sequence is . Identifying its two nonzero columns with the homology of the fiber gives the Wang homomorphism .
For a fibration , the Wang homomorphism belongs to the exact sequence
A transgression is a spectral-sequence differential from a fiber class on the vertical edge to a base class on the horizontal edge.
For a fibration , classes and form a transgressive pair when their images in relative cohomology satisfy . In the Serre spectral sequence this relation is represented by .
Steenrod operations preserve transgressive pairs. With mod-two coefficients, if is transgressive, then so is whenever the square is defined by the instability range. The corresponding statement holds for odd-primary reduced powers and the Bockstein, with the appropriate page shift.

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The Serre spectral sequence is a powerful tool in algebraic topology and homological algebra that provides a method for computing the homology (or cohomology) of a space that can be decomposed into simpler pieces, often using a fibration or a cellular decomposition. ### Overview The Serre spectral sequence arises particularly in the context of a fibration sequence, which is a type of map between topological spaces characterized by having certain lifting properties.