Simply connected closed three-manifolds are homology spheres ($H_i(M;\mathbb{Z})\cong H_i(S^3;\mathbb{Z})$)

A simply connected closed three-dimensional manifold is orientable, since its orientation monodromy factors through its trivial fundamental group. Its first integral homology is the abelianization of that fundamental group and is zero. The universal coefficient theorem for cohomology gives $H^1(M;\mathbb{Z})=0$, and Poincare duality gives $H_2=0$, $H_3=\mathbb{Z}$. Connectedness gives $H_0=\mathbb{Z}$, and duality gives zero homology above dimension three. Thus it is an integral homology sphere, without needing any homeomorphism classification.