A sequence of action potential times, represented mathematically as a point process or a sum of Dirac deltas. Its event counts, intervals and correlations summarize different aspects of neural activity.
An interspike interval is the elapsed time between consecutive action potentials in a spike train. Its probability distribution and dependence on previous activity can reveal a neuronal refractory period even when the average firing rate is unchanged.
For a correctly specified conditional rate, transformed interspike intervals have independent unit-exponential distributions, apart from observation-boundary censoring. Their transforms should be uniform. Distributional checks and serial-correlation checks assess a fitted spike model on held-out data. A history-dependent model must include past spikes in its conditional rate; stimulus-only Poisson spike-train likelihood fitting cannot automatically capture refractoriness.
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