Syphilis

An infectious disease caused by Treponema pallidum.

Involvement of the nervous system by syphilis; it is not confined to a single chronological stage.

A progressive neuropsychiatric syndrome historically described before its cause was securely established.

A late manifestation involving destructive inflammatory lesions called gummas.

Primary lesion classically associated with acquired syphilis; appearance alone does not establish the diagnosis.

Infection acquired before birth; an infant may initially lack visible signs. Historical “hereditary” terminology does not imply Mendelian inheritance.