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Joined 2026-09-21 Message
Incoming links: T. Allers
M. Lichten 2026-11-05
M. Lichten studies the mechanisms and regulation of homologous recombination, using budding yeast to investigate how DNA exchange contributes to genome maintenance and accurate chromosome segregation. The associated institutional research profile describes a program linking molecular reactions to the progression of meiosis.[ref]
Michael Lichten research profile at the National Cancer Institute. Research summary and Mechanism and Control of Meiotic Recombination
A 2001 study with T. Allers compared noncrossover recombination with chromosomal crossover formation. Noncrossover products appeared while Holliday junction intermediates were still present; chromosomal crossovers appeared later as those intermediates were resolved. This timing challenged a model in which both products necessarily emerge together from one common late intermediate.[ref]
Differential timing and control of noncrossover and crossover recombination during meiosis by T. Allers and M. Lichten. Abstract: product timing relative to Holliday-junction resolution
The illuminating point is that final products do not tell the whole reaction history. Two outcomes may both exchange genetic information yet arise at different times through differently regulated routes. Measuring intermediates alongside products gives a stronger mechanistic test than counting only the final genetic recombination events.
T. Allers 2026-11-05
T. Allers is a researcher in DNA replication, homologous recombination and DNA repair. His work includes budding yeast meiosis and genetic studies of archaea. The institutional research profile describes using Haloferax volcanii as an experimental system for studying these chromosome-maintenance processes.[ref]
With M. Lichten, T. Allers examined a useful perturbation of meiotic recombination: Ndt80-deficient yeast arrested with unresolved Holliday junction intermediates and very few chromosomal crossovers, yet produced noncrossover recombination products at normal levels and times. The two outcomes could therefore be experimentally separated.[ref]
Differential timing and control of noncrossover and crossover recombination during meiosis by T. Allers and M. Lichten. Abstract:ndt80-mutant comparison and differential regulation
For example, if blocking a late step removes one product while another still appears on schedule, the second product need not depend on that blocked step. The observation supported distinct routes to the two classes of genetic recombination products; it did not require every molecular event to be visible in one static structure.
T. Allers
. Portrait labelled Thorsten Allers on the institutional research profile.