tandem mass spectrometry selects precursor ions, fragments them, and measures the fragments to constrain precursor identity or structure. In proteomics, fragmentation of peptides provides sequence evidence that can be matched against a database.
Electron capture dissociation fragments multiply charged positive ions after they capture low-energy electrons. In peptide analysis, it can produce backbone cleavages while retaining some modifications that are readily lost by other fragmentation pathways.
Its behavior depends on charge state, structure, and competing relaxation processes. It is a gas-phase ion method in mass spectrometry, distinct from capturing an electron in a neutral solution-phase redox reaction.
Fragmentation of molecular ions induced through electron transfer, useful for preserving and localizing some labile modifications in protein analysis.
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