Anthony W. Parker, professionally known as Tony Parker, works on time-resolved spectroscopy of chemical and biological systems at the Central Laser Facility. His institutional profile describes Raman spectroscopy, infrared spectroscopy, two-dimensional infrared spectroscopy and development of spatially offset Raman spectroscopy.[ref]
One aim of time-resolved spectroscopy is to identify short-lived reaction intermediates rather than observe only the final products. A structural assignment comes from the spectrum; its changing amplitude can then constrain a kinetic model. Those two kinds of information support each other but are not interchangeable.
For an original idealized example, suppose an intermediate disappears in a first-order reaction and its baseline-corrected band amplitude is proportional to its concentration. ThenAt delay , the amplitude is , about36.8% of its starting value. A series of delayed measurements can estimate , whereas a single steady-state spectrum cannot determine that decay time. The model assumes a fixed band strength and a sufficiently fast measurement response.
Parker also coauthored the2022 study of RNA hairpin melting and refolding using a temperature jump and time-resolved infrared observation.[ref]
Measuring RNA UNCG Tetraloop Refolding Dynamics Using Temperature-Jump/Drop Infrared Spectroscopy by C. P. Howe and others. Byline and Abstract
This illustrates how a spectroscopic technique developed for transient chemistry can be applied to structural dynamics of nucleic acids. Articles by others on the same topic
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