Enthalpy by Ciro Santilli 37 Updated 2025-07-16
Adds up chemical energy and kinetic energy.
Wikipedia mentions however that the kinetic energy is often negligible, even for gases.
The sum is of interest when thinking about reactions because chemical reactions can change the number of molecules involved, and therefore the pressure.
To predict if a reaction is spontaneous or not, negative enthalpy is not enough, we must also consider entropy via Gibbs free energy.
Polonium-210 by Ciro Santilli 37 Updated 2025-07-16
The only isotope found on Earth because it occurs as part of the uranium 238 decay chain, i.e., it is not a primordial nuclide.
Interestingly it is a bit less stable than other isotopesL such as Polonium-208 (3 y) and Polonium-209 (124 y), but those aren't in any Earthly radioactive chain so they don't show up on Earth.
Margin Call (2011) by Ciro Santilli 37 Updated 2025-07-16
Video 1.
Peter Sullivan discovers the issue scene from Margin Call
. Source.
Video 2.
Senior partners emergency meeting scene from Margin Call
. Source. God, Jeremy Irons is destroying it!!! And all others too.
Video 3.
Fire Sale of Mortgage Bonds scene from Margin Call
. Source.
Video 4.
Investment Analyst Explains Margin Call by The Plain Bagel
. Source.
Bisulfite sequencing by Ciro Santilli 37 Updated 2025-07-16
The main way to sequence DNA methylation. Converts methylated cytosine to uracil, and then we can sequence those.
Video 1.
Bisulfite Sequencing by Henrik's Lab (2020)
Source. Nothing much new that we don't understand from a single sentence in the animation. But hey, animations!
Analogous problem to the secondary structure of proteins. Likely a bit simpler due to the strong tendency for complementary pairs to bind.
Makes RNA from RNA.
Used in Positive-strand RNA virus to replicate.
I don't think it's present outside viruses. Well regulated organisms just transcribe more DNA instead.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact