Ciro Santilli defines a "model protein" as a protein which has been significantly used in the history of protein science, in analogy to the term model organism.
Key characteristics of model proteins include:
- they are easy to obtain and are stable
- they are important to medical applications
- they are small and easier to understand for early studies
Important model proteins include:
- insulin: as a peptide hormone, this was small. Also it was useful and widely available even at pharmacies, The Eighth Day of Creation says you could get it a Boots, a major British pharmacy chain, and as such was a natural choice for the first sequencing by Frederick Sanger published in 1951
- hemoglobin
- keratin
Radio astronomy is cool because it revealed:The 1974 Nobel Prize in Physics was awarded for pioneering radio astronomy from the late 40s onwards done at the University of Cambridge which was an epicenter of early research in that area, leading to the creation of the Mullard Radio Astronomy Observatory in 1958.
- some very interesting new types of astronomical objects that were not as noticeable in the visible spectrum notably:
- quasars: quasars are extremely redshifted, which means by Hubble's law that they are very far from Earth, so the fact that we could see them at all meant they must have produced immense amounts of light
- pulsars: scientists thought they had found extraterrestrial life when they saw these regularly pulsating signal sources!
- cosmic microwave background which is a major evidence for the Big Bang
- radio wavelengths penetrate Earth's atmosphere better than the visible spectrum making it easier to make ground-based observations
Welcome to my home page!
Starting line:The Eighth Day of Creation explains the "salt" part as that was the usual way to prepare DNA for X-ray crystallography, where something binds with the phosphate groups of DNA
We wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A,). This structure has novel features which are of considerable biological interest.
The paper then shoots down other previously devised helical structures, notably some containing 3 strands or phosphate on the inside.
Then they briefly describe their structure, and promise more details on future articles. This was mostly a short one-page priority note.
Then they drop their shell bomb conclusion:
It has not es~aped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.
Both Wilkins and Rosalind Franklin are acknowledged at the end.
This is natural question because both integer factorization and discrete logarithm are the basis for the most popular public-key cryptography systems as of 2020 (RSA and Diffie-Hellman key exchange respectively), and both are NP-intermediate. Why not use something more provenly hard?
- cs.stackexchange.com/questions/356/why-hasnt-there-been-an-encryption-algorithm-that-is-based-on-the-known-np-hard "Why hasn't there been an encryption algorithm that is based on the known NP-Hard problems?"
Note that the subsequences do not need to be contiguous.
Implementations:
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 3. Visual Studio Code extension installation.
Figure 4. Visual Studio Code extension tree navigation.
Figure 5. Web editor. You can also edit articles on the Web editor without installing anything locally.Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.Video 4. OurBigBook Visual Studio Code extension editing and navigation demo. Source. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact