Chiral analysis refers to the methods and techniques used to identify and separate chiral compounds, which are molecules that exist in two non-superimposable mirror-image forms, known as enantiomers. These enantiomers can have different physical and chemical properties as well as distinct biological activities, making chiral analysis particularly important in fields such as pharmaceuticals, agrochemicals, and food science.
A chiral switch refers to the process of developing a medication that is a specific enantiomer (one of two mirror-image forms) of a drug that has already been marketed as a racemic mixture, which contains both enantiomers. In pharmaceutical chemistry, chirality is significant because the two enantiomers of a chiral molecule can have different biological properties, including variations in efficacy, safety, metabolism, and side effects.
Chirality in chemistry refers to the geometric property of certain molecules that makes them non-superimposable on their mirror images, much like how left and right hands are mirror images of each other but cannot be perfectly aligned on top of one another. This phenomenon arises because of the presence of an asymmetric carbon atom, typically a carbon atom bonded to four different substituents.
Enantiomers are a type of stereoisomer that are non-superimposable mirror images of each other. These molecules have the same molecular formula and connectivity of atoms but differ in their three-dimensional arrangement. Enantiomers typically occur in chiral molecules, which possess a carbon atom bonded to four different substituents, leading to two distinct spatial configurations.
The Gauche effect refers to a conformational preference observed in certain organic molecules, particularly in butane and other alkanes. In these molecules, the Gauche conformation is one where two substituents (or hydrogen atoms) are positioned approximately 60 degrees apart, which can lead to steric interactions and influences on the overall stability of the molecule.
Regioselectivity refers to the preference of a chemical reaction to occur at one specific location over another in a molecule that contains multiple reactive sites. This selectivity is particularly significant in organic chemistry, where a molecule may have several functional groups or double bonds that can potentially react. For example, in the case of electrophilic addition reactions or substitutions, a reagent might attack different positions on a substrate. Regioselectivity indicates which position the reagent preferentially reacts with, leading to a major product.
The Le Bel–Van 't Hoff rule, also known as the Le Bel-Van 't Hoff rule of stereochemistry, relates to the spatial arrangement of molecules and their optical activity. Specifically, it provides insight into the relationship between the number of stereocenters in a molecule and the number of possible stereoisomers.
Molecular configuration refers to the three-dimensional arrangement of atoms within a molecule, particularly how these atoms are bonded together and oriented in space. This includes aspects such as: 1. **Bond Lengths**: The distances between the nuclei of bonded atoms. 2. **Bond Angles**: The angles formed between adjacent bonds at a particular atom. 3. **Dihedral Angles**: The angles between two plane sections formed by four atoms in a molecule.
Optical rotatory dispersion (ORD) is a phenomenon in which the optical rotation of a chiral substance varies with the wavelength of light. When plane-polarized light passes through a chiral medium, the plane of polarization is rotated by an amount that depends on the wavelength of the light. This effect is a consequence of the interaction between the light and the chiral molecules in the substance.
Protein quaternary structure refers to the highest level of structural organization in proteins, where two or more polypeptide chains, known as subunits, come together to form a larger, functional protein complex. Each subunit in a quaternary structure can consist of one or more polypeptide chains, and these subunits can be identical (homomeric) or different (heteromeric).
The stochastic logarithm is a mathematical concept that arises in the field of stochastic calculus, specifically in the study of stochastic processes. It is used to analyze the logarithmic transformation of stochastic processes, especially when these processes are modeled as continuous-time martingales or processes with some form of randomness, such as Brownian motion. In a more formal sense, the stochastic logarithm refers to the logarithmic transformation applied to stochastic processes, particularly in the context of Itô's calculus.
The Misra–Gries algorithm is a streaming algorithm used for identifying the most frequent elements in a data stream. It was developed by Sudhakar Misra and Raghunathan Gries in 1982. This algorithm allows us to track and summarize large sequences of data efficiently, using a limited amount of memory, making it particularly suited for situations where the entire data set cannot fit into memory.
Shot peening is a mechanical process that involves bombarding the surface of a material, usually metal, with small spherical media called "shots." The purpose of shot peening is to improve the mechanical properties of the material, particularly its fatigue strength, ductility, and resistance to stress corrosion cracking. ### Process: 1. **Media Selection**: The shots used can be made of various materials, such as steel, glass, or ceramic, and come in different sizes.
Frankincense is a resin obtained from the Boswellia tree, particularly the species Boswellia sacra, Boswellia serrata, and Boswellia carterii. It has been used for thousands of years for various purposes, including religious rituals, traditional medicine, and as a component in perfumes. The resin is harvested by making incisions in the bark of the tree, allowing the milky sap to ooze out and harden into golden or yellowish-colored beads.
Galbanum is a resin obtained from several species of the Ferula plant, particularly Ferula gummosa and Ferula galbaniflua, which are native to the regions of the Middle East and parts of the Mediterranean. The resin has been known since ancient times and has been used for various purposes, including in perfumes, incense, and traditional medicine. In ancient cultures, including in biblical times, galbanum was valued for its aromatic properties and was often used in religious rituals and offerings.
Geopolymer is a type of inorganic polymer that is primarily formed by the reaction of aluminosilicate materials with an alkaline activator. This process yields a hardened material with properties similar to those of traditional cement. Geopolymers are typically created by mixing materials rich in alumina and silica, such as fly ash, metakaolin, or slag, with an alkaline solution, often containing sodium hydroxide or potassium hydroxide.
Glycerol ester of wood rosin, also known as glycerol rosin, is a resin-derived compound created by the esterification of wood rosin (a natural resin obtained from pine trees) with glycerol. Wood rosin is primarily composed of a mixture of various terpenes, and it is commonly used in a variety of applications, including adhesives, coatings, inks, and chewing gum.
Gum copal is a natural resin that is obtained from certain trees, particularly from the genus Commiphora and the family Burseraceae, which includes species like Boswellia (frankincense) and Canarium. The resin is collected by making incisions in the bark of the tree, allowing the sap to ooze out and harden into a solid form.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either https://OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact