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A short guide-RNA segment important for recognition of many targets. Seed matching supports target prediction but does not establish functional regulation by itself.
An introduced RNA designed to reproduce a mature microRNA guide activity. Delivery, dosage, unintended interactions and immune activation constrain inference from microRNA mimic experiments.
Recruitment of RNA decay machinery by a microRNA-bound effector can shorten the target poly(A) tail and reduce stability, often together with translational repression.
A Caenorhabditis elegans microRNA regulating developmental timing through targets including lin-14. It demonstrates developmental use of a small RNA rather than only defence against foreign sequences.
For a dilute spherical no-slip probe of radius in an isotropic incompressible linear medium at equilibrium, the bead's displacement per unit step force is , where is the bulk shear creep compliance. The fluctuation-dissipation theorem gives one-coordinate displacement variance . Adding the three equal Cartesian contributions proves the displayed relation. In a Newtonian fluid, , so it becomes with the Stokes–Einstein relation .
The particle must sample a continuum response on its scale and remain in thermal equilibrium. A two-dimensional image records only two of the three displacement components; isotropy then gives . Localization noise, confinement and unresolved fast relaxation can otherwise be mistaken for elastic response.
A plot of against for a reaction modeled by Michaelis-Menten kinetics. The slope is , the vertical intercept and the horizontal intercept ; graphical transformation changes how measurement errors are weighted.
Methyl butanoate is the ester . The four-carbon butanoyl group and one-carbon methyl group occupy different sides of the ester linkage.
Hydrolysis yields butanoic acid or butanoate together with methanol, depending on conditions. The carbonyl carbon remains part of the acid-derived fragment.
[ref]
Organic Chemistry by John McMurry. Chapter21, Carboxylic Acid Derivatives: ester identity and hydrolysis
Electrical resistance associated with transfer between intersecting nanowires. Contact geometry, adsorbed ligand and oxide layers, welding and pressure affect it. Reducing nanowire junction resistance can improve a transparent network's sheet resistance without increasing its metal coverage.
The maternal transcript whose local translation produces Oskar; its localisation controls where it can organise germ plasm in Drosophila melanogaster.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





