 Nucleotide-binding leucine-rich repeat receptor

A nucleotide-binding leucine-rich repeat receptor, or NLR, is an intracellular immune-receptor protein characterized by a nucleotide-binding region and leucine-rich repeats. In plants, NLRs can detect pathogen-associated molecules or their effects and initiate defensive signaling.

An NLR can work as a sensor, a signaling helper or part of a paired NLR system. Different individuals can carry different receptor inventories, so one reference genome does not fully describe the species-wide pan-NLRome.^[ref]