The first/only way Ciro could find was with ampy: stackoverflow.com/questions/74150782/how-to-run-a-micropython-host-script-file-on-the-raspbery-pi-pico-from-the-host/74150783#74150783 That just worked and it worked perfectly!
python3 -m pip install --user adafruit-ampy
ampy --port /dev/ttyACM0 run blink.py
TODO: possible with rshell?
Install on Ubuntu 22.04:
python3 -m pip install --user adafruit-ampy
Ctrl + X. Documented by running help repl from the main shell.
Our examples at: rpi-pico-w/upython.
The examples can be run as described at Program Raspberry Pi Pico W with MicroPython.