A checkpoint component participating in kinetochore-associated signalling and mitotic checkpoint complexes.
Its binding interactions help localize checkpoint machinery and assemble inhibitory signals that delay anaphase when attachment is inadequate. A checkpoint component is therefore part of a communication system between chromosome attachment state and cell-cycle progression. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapter 17, The Spindle Assembly Checkpoint
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