A guide-directed DNA nuclease. Target recognition depends on a guide RNA and an appropriate protospacer adjacent motif; cleavage is followed by cellular repair, so cleavage alone does not specify the final allele.
A catalytically inactive form of Cas9 retaining guide-directed DNA binding. Recruitment of regulatory domains makes it a platform for CRISPR interference and CRISPR activation.

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  1. CRISPR genome editing
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