The propensity of a chromatin region to be reached by a specified probe or enzyme under stated conditions. Accessibility, transcription-factor occupancy and regulatory function are related but distinct.
Sequencing-based mapping of DNA cleavage by DNase, used to identify accessible regions and hypersensitive sites. Sequence preferences and digestion conditions require controls.
Profiling accessible DNA through transposase-mediated adapter insertion and sequencing. Enzyme bias, sample preparation and biological cell composition affect the observed accessibility landscape.
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