For X∼N(μ1,C) with a known positive-definite matrix C, the maximum-likelihood estimator of μ is μ=(1TC−1X)/(1TC−11). It is unbiased with variance (1TC−11)−1, attaining the Cramer-Rao bound. It is also the best linear unbiased estimator. Pairwise admissible correlation coefficients alone do not ensure that C is a valid covariance matrix; the entire matrix must be symmetric and a positive semidefinite matrix. Inverse-based formulas require positive definiteness.
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