An estimator of a parameter is unbiased when for every parameter value in the model.
An estimator is conditionally unbiased for a parameter if its expectation, conditional on the specified observation or selection event, equals that parameter. Unconditional unbiasedness does not imply this property after selection. Independent new-stage data and the Rao-Blackwell theorem can provide useful constructions.
A UMVCUE has minimum conditional variance among all estimators unbiased in the selected experiment for every parameter. For independent Gaussian stage estimates with information , continuation , total information and pooled estimate , Rao-Blackwellization of the fresh estimate gives , where . The conditional family has complete sufficient statistic , so the Lehmann–Scheffé theorem establishes the optimum. A conditional-likelihood bias correction does not automatically have this unbiasedness property.
In a linear model , a linear estimator has the form . It is unbiased for exactly when . A best linear unbiased estimator minimizes its covariance, or its variance for a scalar target, among all estimators satisfying this constraint.
A best linear unbiased estimator minimizes covariance among linear estimators unbiased for the same target. In , assume , is a full-column-rank design matrix and the known covariance matrix is a positive-definite matrix. The best linear unbiased estimator of the coefficient vector is . A spatial trend estimate excludes the correlated residual prediction included in universal kriging.
For with a known positive-definite matrix , the maximum-likelihood estimator of is . It is unbiased with variance , attaining the Cramer-Rao bound. It is also the best linear unbiased estimator. Pairwise admissible correlation coefficients alone do not ensure that is a valid covariance matrix; the entire matrix must be symmetric and a positive semidefinite matrix. Inverse-based formulas require positive definiteness.
For independent unbiased estimators of a common mean with known positive variances , the linear unbiased estimator with smallest variance has weights and variance . Unbiasedness requires . Minimizing by a Lagrange multiplier gives the weights, and the strictly positive diagonal Hessian matrix proves a unique global minimum. This conclusion requires no normality assumption.
A weight gives more weight to a more precise estimate. In random-effects meta-analysis the variance of the corresponding marginal distribution is , giving weight . A percentage weight divides the individual weight by the sum of all weights.

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