In a linear model , a linear estimator has the form . It is unbiased for exactly when . A best linear unbiased estimator minimizes its covariance, or its variance for a scalar target, among all estimators satisfying this constraint.
A best linear unbiased estimator minimizes covariance among linear estimators unbiased for the same target. In , assume , is a full-column-rank design matrix and the known covariance matrix is a positive-definite matrix. The best linear unbiased estimator of the coefficient vector is . A spatial trend estimate excludes the correlated residual prediction included in universal kriging.
For with a known positive-definite matrix , the maximum-likelihood estimator of is . It is unbiased with variance , attaining the Cramer-Rao bound. It is also the best linear unbiased estimator. Pairwise admissible correlation coefficients alone do not ensure that is a valid covariance matrix; the entire matrix must be symmetric and a positive semidefinite matrix. Inverse-based formulas require positive definiteness.
For independent unbiased estimators of a common mean with known positive variances , the linear unbiased estimator with smallest variance has weights and variance . Unbiasedness requires . Minimizing by a Lagrange multiplier gives the weights, and the strictly positive diagonal Hessian matrix proves a unique global minimum. This conclusion requires no normality assumption.

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