EDS1, ENHANCED Disease SUSCEPTIBILITY 1, is a plant immunity signaling component that forms complexes with partner proteins, including PAD4. Such interactions connect particular immune-recognition pathways to changes in defence activity.
The pathway is not present unchanged in every plant. Comparative genomic work identified convergent losses of EDS1, PAD4 and associated components, providing evidence for coevolution of an interacting molecular system.[ref]
EDS1 and PAD4 pathway-loss study by Erin L. Baggs and others. Abstract, convergent losses and pathway coevolution
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