A gauge anomaly destroys a gauge redundancy needed to remove unphysical states and makes the quantum gauge theory inconsistent unless the anomaly cancels.
Anomaly cancellation is the vanishing of every gauge and mixed gauge-gravitational anomaly after summing over all chiral fermions. It is a consistency condition for a quantum gauge theory.
In each Standard Model generation, quark and lepton hypercharges cancel the , , , , and mixed gauge-gravitational anomalies. The four left-handed doublets also avoid the global Witten anomaly.
In normalization , one Standard Model generation has left quark and lepton doublet hypercharges and , and right singlet hypercharges . Including colour multiplicity, . On every left doublet , and all right fields have , so the mixed weak-hypercharge gauge anomaly vanishes. The cubic left trace is , and the right trace is . Their difference is zero, proving generation-by-generation cancellation of these two anomalies.
A mixed gauge-gravitational anomaly has one gauge-current insertion and two stress-tensor insertions. For a four-dimensional symmetry its coefficient is the sum of the left-handed Weyl-fermion charges, with right-handed fermions counted as left-handed conjugates.

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