I. G. Panyutin studied the physical chemistry of DNA strand exchange. In 1994, work with P. Hsieh measured spontaneous branch migration, the motion of an exchange junction along homologous double-stranded DNA.[ref]
The experiments varied temperature and ions while using defined DNA substrates. Removing magnesium accelerated the reported process by roughly a thousandfold. The comparison illustrates why an observed reaction rate is not a property of the DNA sequence alone: solution conditions can alter junction geometry and therefore how readily exchange proceeds.[ref]
The kinetics of spontaneous DNA branch migration by I. G. Panyutin and P. Hsieh. Abstract; temperature/ionic conditions and magnesium comparison
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