For positive-definite Hermitian matrices , Klein's inequality gives
with equality exactly when . To prove it, let be their eigenvalues and their orthonormal eigenvectors. The weights have row and column sums one. The difference between the two sides is
by the scalar logarithm inequality . Equality requires whenever , implying . Limits extend the result to positive semidefinite matrices with the appropriate support condition. Applying it to trace-one matrices proves nonnegativity of quantum relative entropy.

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