Membrane capacitive ion budget ($\Delta c=C_{m}A\Delta V/(zF\mathcal{V})$)

When a single ion species supplies the net charging of a cell membrane, its bulk concentration increment is $\Delta c=C_{m}A\Delta V/(zF\mathcal{V})$. Opposing ionic Electric currents can make gross entry exceed this minimum net electric charge budget. A large membrane potential change can coexist with approximate bulk electroneutrality.