On the main sequence, central hydrogen burning converts four protons into helium, positrons, neutrinos and released energy. The net reaction is , with positron annihilation contributing to the total roughly release before subtracting escaping neutrino energy. In the low-mass main-sequence stars of an old globular cluster, the proton–proton chain generally dominates. The CNO cycle makes the same net conversion and becomes important in hotter burning regions.
After central hydrogen exhaustion, a subgiant contracts its helium core and establishes a hydrogen-burning shell. On the red giant branch, that shell supplies most of the luminosity, commonly through the temperature-sensitive CNO cycle, while the inert helium core grows and becomes supported mainly by electron degeneracy pressure. The envelope expands and its surface cools. The helium core is not yet powered by helium nuclear fusion.
Helium ignition in a sufficiently low-mass degenerate core produces the helium flash, removing the strong electron degeneracy pressure dominance. A horizontal-branch star subsequently burns helium in its core through the Triple-alpha process, , and through . A surrounding hydrogen-burning shell can continue simultaneously.
After central helium exhaustion, the Asymptotic giant branch has an inert carbon-oxygen core with a helium-burning shell and an outer hydrogen-burning shell. Alternation between quiescent burning and helium-shell thermal pulses drives mixing and substantial mass loss. Subsequent post-asymptotic giant branch evolution exposes a hot core that may ionize its expelled envelope as a planetary nebula. Finally a white dwarf cools mainly by loss of stored thermal energy, rather than sustained central nuclear fusion.

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