Write the linear mean model asThe errors are independent but heteroscedastic. Minimizing the unweighted residual sum of squaresgives the normal equationThus, provided ,Since ,Hence it is an unbiased estimator. This is the least-squares part of the estimators for a Poisson exposure model.
Ignoring terms independent of , the log-likelihood isIts score function isSince , the interior critical point is the maximum, givingThe sum of independent Poisson distributions is Poisson with mean , soThus the maximum-likelihood estimator is also unbiased.
PutIndependence and givewhereas givesThe Cauchy-Schwarz inequality, applied to and , yieldsConsequentlyEquality holds exactly when all positive exposures are equal. This is the variance comparison for Poisson exposure estimators.
Both alternatives have larger , so use upper-tail rejection regions. Let be the 95th quantile of the standard normal distribution.
For the likelihood estimator,When is large, the normal approximation to the Poisson distribution gives, under ,An approximate size- test therefore rejects when
When every is large, independently. A linear combination of independent normal variables is normal, so under ,The corresponding approximate size- test rejects whenIn both cases the null rejection probability is approximately , while values near the alternative mean increasingly fall in the rejection region as the total exposure grows. These are the normal-approximation tests for a Poisson exposure model.
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