Take and
Its Jacobian matrix and determinant are
Thus its total derivative is invertible everywhere, and the inverse function theorem makes it locally invertible. But , so it is not injective and has no global inverse on its image. The domain is open and connected as required.
No. On let
It is a bijection onto , with inverse . Nevertheless is singular whenever . Set-theoretic invertibility, even together with a continuous inverse, does not force invertibility of the total derivative. If the inverse were assumed differentiable, the chain rule applied to would force both derivatives to be invertible; that stronger assumption is absent here.

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