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Chemical substance

Lipid

Phospholipid

{title2=$\mathrm{PIP}_2$}
{wiki}

= PIP2
{c}
{synonym}

<Phosphatidylinositol 4,5-bisphosphate> is a membrane <phospholipid> whose inositol headgroup bears additional <phosphate> groups at positions 4 and 5. Its charged headgroup interacts with membrane-associated <proteins>.

Cleavage of <phosphatidylinositol 4,5-bisphosphate> generates membrane-associated <diacylglycerol> and soluble <inositol trisphosphate>. These products act as <second messengers>, connecting a change in a membrane lipid with intracellular <signal transduction>.

Phosphatidylinositol 4,5-bisphosphate

AP-2 complex

Diacylglycerol

Past exam of the biochemistry course of the University of Cambridge / 2025 / Paper 1 / Section II / 5 / Solution

Past exam of the biochemistry course of the University of Cambridge / 2025 / Paper 1 / Section II / 7 / Solution

Past exam of the biochemistry course of the University of Cambridge / 2025 / Paper 4 / Section I / 1 / Solution

codex/pip2

Phosphatidylinositol 4,5-bisphosphate ( $PIP_{2}$ )

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Phosphatidylinositol 4,5-bisphosphate (PIP2​)