A guide RNA associated with Piwi-family proteins. Most characterized animal piRNA pathways use Dicer-independent processing of single-stranded precursors; the approximately 21-nucleotide C. elegans 21U RNAs are distinct from the longer typical fly and mammalian piRNAs.[ref]
A class of approximately 21-nucleotide Caenorhabditis elegans piRNAs associated with PRG-1. They are not generated by the standard fly ping-pong system.
Reciprocal guide-directed cleavage produces new piRNA ends from complementary precursor or target RNAs. A 10-nucleotide overlap of opposite-strand 5′ ends supports this mechanism but does not prove amplification in every piRNA pathway.
A genomic source of piRNA precursor transcripts, often containing fragments of transposable elements. Cluster-derived guides can recognize related active elements elsewhere in the genome.

Ancestors (6)

  1. Small regulatory RNA
  2. Ribonucleic acid
  3. Nucleic acid
  4. Polymer
  5. Chemistry
  6. Home

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