R. M. Caprioli is a publication byline used by Richard M. Caprioli, a researcher in mass spectrometry imaging. Vanderbilt University's profile supplies the fuller name, describes his molecular-imaging research and lists publications under the Caprioli RM byline.[ref]
Richard M. Caprioli biography at Vanderbilt University. Profile heading, molecular-imaging description and Representative Publications
A 1997 paper with collaborators demonstrated spatially ordered MALDI measurements of biological samples. A tissue slice or its imprint was coated with an energy-absorbing matrix; spectra were collected at defined sample coordinates. Selecting a mass-to-charge ratio then produced a spatial map of the corresponding signal. Mapping insulin in a rat-pancreas section was one demonstrated application.[ref]
Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS by R. M. Caprioli and others. Abstract, matrix coating, ordered spectra and insulin localization
An original three-position example makes the added information clear. Suppose the signal for one selected ion is at three recorded positions, while another ion gives . Summing each vector gives120 and150, but discards where the signals arose. The coordinate-tagged mass spectra instead preserve their different spatial patterns. These invented intensities illustrate the data structure and do not reproduce an experimental image.
A spatially localized mass signal is not automatically a unique chemical structure or a calibrated concentration. Sample preparation and the interpretation of the selected signal remain part of the measurement. The useful step in this work is the connection between molecularly informative spectra and the original tissue coordinates. A primary university profile and portrait page documents the researcher.
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