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Joined 2026-09-21 Message
Incoming links: Salmonella
Salmonella 2026-11-05
Salmonella is a genus of bacteria whose members include organisms associated with intestinal and systemic infections. Species and serovar distinctions matter: the genus name does not specify one host range or one clinical course. Its members also provide experimentally tractable examples of gene regulation.
In the FourU RNA thermometer, base pairing in a messenger RNA controls access to a ribosome-binding region. Structure-probing and translation experiments showed how temperature-dependent opening can alter expression of a heat-shock protein. [ref]
FourU: a novel type of RNA thermometer in Salmonella by Torsten Waldminghaus and others. 2007, abstract: agsA untranslated-region structure, mutation effects and temperature-dependent ribosome binding
The example separates a change in RNA structure from a change in DNA sequence: environmental conditions can alter the output of the same encoded regulatory element. Torsten Waldminghaus Created 2026-10-20 Updated 2026-11-05
Researcher in bacterial gene regulation. Waldminghaus and collaborators investigated the FourU RNA thermometer in Salmonella, linking temperature-dependent RNA structure with control of gene expression.[ref]
FourU: a novel type of RNA thermometer in Salmonella by Torsten Waldminghaus and others. Title, author list and reported study