Past exam of the mathematical physiology course of the University of Oxford 2023 2 d Solution 2026-10-25
Take and let with the other parameters fixed. The nullclines are the cubic polynomial graph and the line . In the phase plane, increases below the cubic polynomial graph and decreases above it; increases below the line and decreases above it. The fast ordinary differential equation, in time , freezes and gives .
At , the fast roots are . Their linear stability follows from , and . Thus a fixed falls towards the resting branch, whereas a fixed rises towards . If , the first fast segment instead settles down towards , followed by the same recovery excursion. The threshold is the leading singular perturbation threshold; finite- corrections matter for initial values approaching with .
LetThese are the roots of . The outer branches and of the critical manifold are attracting under fast motion; the middle branch is repelling. The full excursion has four stages.
- Fast activation: nearly horizontal movement towards , on the time scale, apart from the usual matching tails.
- First slow phase: motion along from down to . Here rises and slowly falls, because on the positive outer branch. This takes order-one time for fixed .
- Fast repolarization: near the right fold point of a critical manifold, the attracting branch ends. With nearly constant, drops to the negative root of . The jump takes the fast time scale; a thin neighborhood of the fold has an intermediate fold delay.
- Second slow phase: motion along the negative attracting branch from towards from below, while falls towards zero. This is the refractory recovery and has order-one duration to a fixed small cutoff; exact return to the equilibrium takes infinite time.
For this cubic polynomial, the landing point is explicit. Since , comparison of the quadratic coefficients givesThus a graph of has a rapid rise, a slowly falling elevated plateau, a rapid fall through zero to a negative undershoot, and a slow approach back to zero. The figure shows both the phase plane and a computed time trace. The smaller initial perturbation stays near the resting branch and produces no elevated plateau.
The four-stage description concerns the singular limit. Close to a simple fold point of a critical manifold, balancing the local quadratic activation term with the slow drift gives and for fixed parameters. These layers shrink compared with the slow phases and do not alter the leading time integrals below.
Past exam of the mathematical physiology course of the University of Oxford 2023 2 f Solution 2026-10-25
The requested second phase is the second slow recovery phase, beginning after the downward fast jump. Its starting point is , fixed by , with the negative root chosen. Along it the same chain rule givesThe approach is to zero from below. Thus, if the printed cutoff is a signed value, it must satisfy and . If denotes a small positive magnitude, the endpoint is instead . To express both conventions unambiguously, put and writeThere is no positive small endpoint on this leading slow branch. A positive cutoff would require a different event or finite- oscillatory recovery.
For bounded negative and ,Integration therefore gives the useful more detailed approximationTaking also , the leading logarithm isIndeed near zero, and the slow equation is , so at fixed the exact leading logarithmic coefficient is . Its large- limit is , agreeing with the integral.
The order of approximation matters: first take the singular limit at fixed , then the large- and small-cutoff limits. For simultaneous limits, a sufficient separation near rest is . Otherwise the fast and recovery time scales merge, and these slow-branch formulas need not describe the late-time motion.
Past exam of the mathematical physiology course of the University of Oxford 2023 3 f Solution 2026-10-25
On the descending part of the graph, mark the two tangency points whereChoose the crossings that enclose the portion with . For fixed strictly between these values and sufficiently small , the unique equilibrium is a repelling equilibrium by part (e). The endpoints here are leading singular limit values; at finite the boundaries instead solve and approach these tangencies when the crossings are nondegenerate.
There is a necessary qualification: such an interval exists only when is large enough that the descending graph actually attains slopes below . If , one needs . The supplied graph has a very steep descending section, but an arbitrarily small positive need not satisfy this condition. For , numerical evaluation gives , so the leading threshold is . A graph alone does not remove this parameter restriction.
The fast motion is especially informative. In fast time ,At leading order is constant, so fast paths are straight lines with slope . Along such a line, the fast eigenvalue at the nullcline isIt is negative on the two outer attracting segments and positive on the intervening repelling segment. The tangencies defining are consequently the fold points of a critical manifold when it is expressed in the coordinates . They are not generally the maximum and minimum of itself.
For , slow motion on an attracting segment followsOn the left attracting segment this moves towards increasing ; on the right attracting segment it moves towards decreasing . Each segment ends at a tangency and is followed by a fast jump along a line of slope to the other attracting segment. This constructs the limiting relaxation oscillation. The figure uses , for which and ; the marked endpoints change with .
To justify existence of a periodic orbit of the full planar system, rather than just draw a formal cycle, first establish a compact trapping region. The positive quadrant is forward invariant: at , , and at , . MoreoverChoose above the initial store value. Since when ,Thus the rectangle , is a positively invariant set if and the initial point lies inside it. Every forward solution is bounded. There are no equilibria on its axes for , and its sole interior equilibrium is a hyperbolic equilibrium point with both eigenvalues having positive real parts in the strict unstable range. A sufficiently small neighborhood of this repelling equilibrium has outward flow; deleting it leaves a compact trapping region with no equilibria. The Poincaré-Bendixson theorem then supplies a periodic orbit.
Hence periodic solutions exist throughout the strict unstable interval, interpreted with the finite- correction above. This argument establishes existence, without asserting uniqueness, the criticality of possible endpoint Hopf bifurcations, or absence of coexisting periodic orbits outside the interval.
Singular limit 2026-10-25
A singular limit is a parameter limit in which the governing problem loses an order, changes type, or otherwise changes its qualitative solution structure. For , setting produces the algebraic constraint and can omit fast transients required by the initial data.

