Assembly and positioning of the biological translation machinery at a selected start. ribosome recruitment, scanning and start-codon recognition are distinguishable processes.
A biological translation inhibitor with preferential effects on early ribosomes, used in initiation-site profiling. Peak size need not equal initiation flux.
A biological translation inhibitor used to enrich ribosomes near initiation sites while much ongoing elongation runs off. Exposure time and trapping kinetics affect inferred initiation positions.
Initiation after a preceding biological translation event on the same RNA, often involving retention of a small subunit and reacquisition of required factors. Upstream reading-frame effects depend on these kinetics.
Bypass of a potential initiation site by a scanning small-subunit complex, allowing initiation farther downstream. Local context and factor availability affect the probability of selection.
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