Evolution by Ciro Santilli 40 Updated 2025-07-16
Video 1.
The Evolution of Bacteria on a 'Mega-Plate' Petri dish by Kishony Lab (2016)
Source. They've made a huge Petri dish with bands of different concentrations of antibiotic, and then they visualize Escherichia coli mutations as new strains manage to make their way into the highest antibiotic concentration strip. mind blowing.
Life by Ciro Santilli 40 Updated 2025-07-16
Whatever it is that biology studies.
Or: how to learn X.
This pops up on Reddit every week.
The right question is: what is the most awesome project I can do to improve the world?
Then, once you decide to try one, if that involves programming, only then learn to program to achieve that goal. And don't stop learning what's needed until you either get the thing done, or decide that it is actually not a good idea, or not possible, or that there is something else more important to be done first.
But if doesn't involve programming, then don't learn to program, and learn whatever you actually need to reach that goal instead.
Having that goal is the only way to be motivated to do something.
This is the essence of backward design.
Charles Bukowski by Ciro Santilli 40 Updated 2025-07-16
Video 1.
Something for the touts
. Source.
We have everything and we have nothing
And some men do it in churches
And some men do it by tearing butterflies in half
and some men do it in Palm Springs
Laying it into butter-blondes with Cadillac souls
This stuck to Ciro's mind for some reason. His brain just keeps completing the sentence, over and over:
Ciro Santilli does it in his computers and in his labs!

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either https://OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact