Discord (software) Updated 2025-07-16
You gotta be born after the year 2000 to understand it.
This is becoming more and more popular as a group chat with channels and threads possibility as of 2020.
Very similar to Slack.
They force your username to have 4 random digits? www.reddit.com/r/discordapp/comments/43kjdl/whats_the_number_next_to_the_username/
Not possible to anonymously join just one server without creating a new account? What's the point of servers then! www.reddit.com/r/discordapp/comments/6gmjl7/changing_nick_before_joining_a_new_server/ Oh, also nicks don't hide your username from the server in any way, you can get the original username by just clicking on the person's username.
No proper threaded discussion without creating new channels? As of 2022 there is kind of a way, but it was a bit obtuse.
As of 2022 they also have a school hub: support.discord.com/hc/en-us/articles/4406046651927-Discord-Student-Hubs-FAQ which auto creates groups by university email access. Good idea, and shows popularity amongst that user group.
Servers don't have an ID to join them? www.reddit.com/r/discordapp/comments/b9zdt6/join_discord_server_from_id/
Can only make public servers if you have 1000 members?? support.discord.com/hc/en-us/articles/360023968311 Why so much bullshit?? www.reddit.com/r/discordapp/comments/6jouf8/how_do_i_make_my_server_public/
Microsoft PowerPoint Updated 2025-07-16
Microsoft Windows Updated 2025-07-16
A monopolistic operating system that only exists in the 2010's because of the IBM-linked historical lock-in and constant useless changes of the Microsoft Word document format to prevent cross operability.
It offers no technical advantages over free Linux distros in the late 2010's, and it is barely impossible to buy a non-Mac computer without paying for it, which should be illegal. European Union, time to use your regulatory powers.
The following anecdote illustrates Windows' pervasiveness. Ciro Santilli was once tutoring a high school student in Brazil, and decided to try and get her into programming. When the "Windows is not free" subject came up, the high school student was shocked: "I paid 100 dollars for this?". She never even knew it was there. To her, it was "just a computer".
Laws should really be passed forcing OEMs to allow you to not buy Microsoft Windows when buying a computer, European Union, why have you failed me in 2016??? en.wikipedia.org/wiki/Bundling_of_Microsoft_Windows
blog.zorinaq.com/i-contribute-to-the-windows-kernel-we-are-slower-than-other-oper/ I Contribute to the Windows Kernel. We Are Slower Than Other Operating Systems. Here Is Why. by Marc Bevand (2013) has some interesting remarks:
There's also little incentive to create changes in the first place. On linux-kernel, if you improve the performance of directory traversal by a consistent 5%, you're praised and thanked. Here, if you do that and you're not on the object manager team, then even if you do get your code past the Ob owners and into the tree, your own management doesn't care. Yes, making a massive improvement will get you noticed by senior people and could be a boon for your career, but the improvement has to be very large to attract that kind of attention.
Mycoplasma genitalium Updated 2025-07-16
www.lgcstandards-atcc.org/products/all/49896.aspx:
- £355.00 in 2019
- biosafety level: 2
Reproduction time: www.quora.com/unanswered/How-long-do-Mycoplasma-bacteria-take-to-reproduce-under-optimal-conditions
Has one of the smallest genomes known, and JCVI made a minimized strain with 473 genes: JCVI-syn3.0.
The reason why genitalium has such a small genome is that parasites tend to have smaller DNAs. So it must be highlighted that genitalium can only survive in highly enriched environments, it can't even make its own amino acids, which it normally obtains fromthe host cells! And because it cannot do cellular respiration, it very likely replicates slower than say E. Coli. It's easy to be small in such scenarios!
Power, Sex, Suicide by Nick Lane (2006) section "How to lose the cell wall without dying" page 184 has some related mentions puts it well very:
One group, the Mycoplasma, comprises mostly parasites, many of which live inside other cells. Mycoplasma cells are tiny, with very small genomes. M. genitalium, discovered in 1981, has the smallest known genome of any bacterial cell, encoding fewer than genes. Despite its simplicity, it ranks among the most common of sexually transmitted diseases, producing symptoms similar to Chlamydia infection. It is so small (less than a third of a micron in diameter, or an order of magnitude smaller than most bacteria) that it must normally be viewed under the electron microscope; and difficulties culturing it meant its significance was not appreciated until the important advances in gene sequencing in the early 1990s. Like Rickettsia, Mycoplasma have lost virtually all the genes required for making nucleotides, amino acids, and so forth. Unlike Rickettsia, however, Mycoplasma have also lost all the genes for oxygen respiration, or indeed any other form of membrane respiration: they have no cytochromes, and so must rely on fermentation for energy.
Downsides mentioned at youtu.be/PSDd3oHj548?t=293:
- too small to see on light microscope
- difficult to genetically manipulate. TODO why?
- less literature than E. Coli.
Data:
- www.ncbi.nlm.nih.gov/bioproject/97 contains genome, genes, proteins.
- www.genome.jp/kegg-bin/show_pathway?mge01100 all known pathways. TODO: numerical reaction coefficients? Which enzyimes mediate what? Appears to factor pathways across organisms, which is awesome.
Mycoplasma mycoides Updated 2025-07-16
GNU Debugger Updated 2025-07-16
Just add GDB Dashboard, and you're good to go.
Micro Bit GPIO Updated 2025-07-16
Micro Bit simulator Updated 2025-07-16
Netflix and chill Updated 2025-07-16
On the Relative Motion of the Earth and the Luminiferous Ether Updated 2025-07-16
This paper is in the public domain and people have uploaded it e.g. to glorious Wikisource: en.wikisource.org/wiki/On_the_Relative_Motion_of_the_Earth_and_the_Luminiferous_Ether including its amazing illustrations.
Fig 3 from On the Relative Motion of the Earth and the Luminiferous Ether
. Source. Amazing 3D technical drawing from the 19th century!!! Continuous problems are simpler than discrete ones Updated 2025-07-16
Basically, continuity, or higher order conditions like differentiability seem to impose greater constraints on problems, which make them more solvable.
Some good examples of that:
- complex discrete problems:
- simple continuous problems:
- characterization of Lie groups
Khronos Group Updated 2025-07-16
Quantum field theory lectures Updated 2025-07-16
Discrete Fourier transform Updated 2025-07-16
Output: another sequence of complex numbers such that:Intuitively, this means that we are braking up the complex signal into sinusoidal frequencies:and is the amplitude of each sine.
- : is kind of magic and ends up being a constant added to the signal because
- : sinusoidal that completes one cycle over the signal. The larger the , the larger the resolution of that sinusoidal. But it completes one cycle regardless.
- : sinusoidal that completes two cycles over the signal
- ...
- : sinusoidal that completes cycles over the signal
Motivation: similar to the Fourier transform:In particular, the discrete Fourier transform is used in signal processing after a analog-to-digital converter. Digital signal processing historically likely grew more and more over analog processing as digital processors got faster and faster as it gives more flexibility in algorithm design.
- compression: a sine would use N points in the time domain, but in the frequency domain just one, so we can throw the rest away. A sum of two sines, only two. So if your signal has periodicity, in general you can compress it with the transform
- noise removal: many systems add noise only at certain frequencies, which are hopefully different from the main frequencies of the actual signal. By doing the transform, we can remove those frequencies to attain a better signal-to-noise
Sample software implementations:
- numpy.fft, notably see the example: numpy/fft.py
DFT of with 25 points
. This is a simple example of a discrete Fourier transform for a real input signal. It illustrates how the DFT takes N complex numbers as input, and produces N complex numbers as output. It also illustrates how the discrete Fourier transform of a real signal is symmetric around the center point. Flatpak Updated 2025-07-16
Dizi (instrument) Updated 2025-07-16
Django (web-framework) Updated 2025-07-16
React setups:
DNA sequencing milestone Updated 2025-07-16
Most of these are going to be Whole-genome sequencing of some model organism:en.wikipedia.org/wiki/Whole_genome_sequencing#History lists them all. Basically th big "firsts" all happened in the 1990s and early 2000s.
- 1975 by Sanger et al.: 5 kbp of the single-stranded bacteriophage ΦX174 using Sanger's radiolabelling method
- 1981 by Sanger et al.: 17 kbp of human mitochondrial DNA via Sanger method, known as the Cambridge Reference Sequence
- 2003: Human Genome Project (3 Gbp)
Smartphone Updated 2025-07-16
Structure of the mitochondria Updated 2025-07-16
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