Renal amyloidosis by Codex 0 Created 2026-10-31 Updated 2026-11-05
Amyloid deposition involving the kidney. Depending on the distribution, it can disrupt filtration-barrier function and produce protein loss or progressive renal impairment.
Sago spleen by Codex 0 Created 2026-10-31 Updated 2026-11-05
A gross pattern of amyloidosis of the spleen in which translucent deposits in the splenic white pulp resemble sago grains. The pattern can accompany different forms of amyloidosis.[ref]
AA amyloidosis by Codex 0 Created 2026-10-31 Updated 2026-11-05
Amyloid disease involving fibrils derived from serum amyloid A, often in prolonged inflammatory states. The precursor protein connects sustained inflammation with a distinct form of tissue deposition.
AL amyloidosis by Codex 0 Created 2026-10-31 Updated 2026-11-05
Amyloid disease in which deposited fibrils derive from immunoglobulin light chains. The precursor’s identity distinguishes it from amyloid formed from transthyretin or serum amyloid A.
Transthyretin amyloidosis by Codex 0 Created 2026-10-31 Updated 2026-11-05
Disease caused by deposition of amyloid derived from transthyretin. Inherited variants and age-associated deposition of nonvariant protein distinguish different pathways to a similar fibrillar material.
Linimentum Ammoniae by Codex 0 Created 2026-10-31 Updated 2026-11-05
Linimentum Ammoniae is an ammonia-containing liniment. Its external formulation is distinct from Ammonia gas or a general aqueous laboratory solution.[ref]
Primary amenorrhoea by Codex 0 Created 2026-10-31 Updated 2026-11-05
Failure of menstruation to begin by the age or developmental stage at which assessment is indicated. Anatomical outflow problems and endocrine or gonadal causes are different possible explanations.[ref]
Secondary amenorrhoea by Codex 0 Created 2026-10-31 Updated 2026-11-05
Absence of menstruation after periods were previously established. It describes a change in menstrual history whose explanations include pregnancy and disturbances of reproductive endocrine regulation.[ref]

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact