Journal of Clinical Investigation50(1971),1776–1780; DOI10.1172/JCI106667. Publisher full byline verifies Barry M. Brenner,Julia L. Troy,Terrance M. Daugharty. Abstract: surface-glomerulus Wistar rats,servo-null capillary-pressure measurements,hydrostatic/oncotic-pressure estimates and single-nephron filtration. An October1971 correction is linked by the publisher; article text uses qualitative experimental conclusions and a separate explicitly hypothetical calculation,not the original numerical estimates.
Nature Genetics20(1998),344–351; DOI10.1038/3813. Initial-only first byline retained. Abstract: Rpe65-deficient mice, electroretinography, absent rhodopsin despite opsin apoprotein, altered retinoid composition. Distinguishes necessity in this knockout model from proof of every biochemical step.
Molecular Human Reproduction6(2000),677–680; DOI10.1093/molehr/6.8.677. Initial-only first byline retained. Abstract: cells from IVF follicular aspirates, preincubation,24h FSH stimulation, wash then2h testosterone challenge. The assay separates longer-term induction from substrate depletion.
PLOS ONE9(2014),e105687; DOI10.1371/journal.pone.0105687. Original full byline verifies Diane Rebourcet. Transgenic selective Sertoli-cell ablation in adult mice; germ-cell loss, Leydig-cell decline and retained tubular architecture. Abstract and Results/Figures1,2,6. Animal-model results, not a proposed human treatment.
PNAS96(1999),7962–7967; DOI10.1073/pnas.96.14.7962. Abstract and immunolocalization: nephrin localized to the glomerular podocyte slit diaphragm. Initial-only first byline retained; full identity not guessed. Full text pmc.ncbi.nlm.nih.gov/articles/PMC22170/ .
Human Gene6557, RefSeq summary: encodes NKCC2 on the luminal membrane of thick-ascending-limb and macula-densa cells. Consulted LEVEL007. Gene and protein are distinguished; no clinical advice or quantitative fraction of total kidney salt transport inferred.
NIH Office of Dietary Supplements, Introduction: fat-soluble compound family, K1/K2 forms and vitamin-K-dependent carboxylase. Used for biochemical definition only; no dose, personal treatment or medication-change recommendations.
American Journal of Physiology258,H647–H654 (1990), DOI10.1152/ajpheart.1990.258.3.H647. Abstract: in-situ capillary microperfusion, tube hematocrit, vehicle/heat-denatured-enzyme controls and no significant velocity change.
Verified locator: American Journal of Physiology210(6),1293–1298,June1966; DOI10.1152/ajplegacy.1966.210.6.1293. Indexed byline M.Burg,J.Grantham,M.Abramow,J.Orloff retained without expansion. Original method-paper record verified; perfusion-method context also documented by the2022 Knepper remembrance. Do not confuse with the1997 reprint/commentary.
By Mia Phillipson and others.
Verified locator: Journal of Experimental Medicine203(12),2569–2575(2006), DOI10.1084/jem.20060925. Byline verifies Mia Phillipson. Abstract/Results: intravital time-lapse microscopy in inflamed mouse postcapillary venules; crawling to exit sites distinct from initial adhesion. Figure1 specifies timed adhesion criteria. No clinical extrapolation.
Verified locator: Chapter1, sections1and5: dry-air/moist-air composition; humidity ratio Eq7, molecular-mass ratio0.621945 Eq8, specific humidity Eq9, distinctions from relative humidity. Definition and mass ratio are unit-independent; ideal-gas approximation used in worked derivation.
British Journal of Nutrition 39(3),557–566 (1978); DOI10.1079/BJN19780071. Authors M. J. Dauncey, P. R. Murgatroyd and T. J. Cole. The indexed abstract describes a heat-sink direct calorimeter, open-circuit indirect measurements and evaporative heat loss inferred from inlet/outlet wet-and-dry-bulb temperatures and airflow.
Journal of Clinical Investigation52(1973),612–623; DOI10.1172/JCI107223. Publisher verifies both full bylines. Abstract: isolated perfused rabbit medullary thick ascending limb; net fluid transport remained near zero under imposed osmotic gradients, while tubular NaCl concentration fell. The historical chloride-pump interpretation is not adopted as a complete modern molecular mechanism.
Journal of Clinical Investigation49(1970),1838–1846; DOI10.1172/JCI106401. Original publisher byline verifies Juha P. Kokko. Abstract: isolated perfused rabbit descending thin limbs, water efflux when bath osmolality raised with NaCl or raffinose, low sodium permeability. Restricted to tested segment and preparation.
Institutional anatomical specimenEXC002 and voiceover: cortex, pyramids, renal columns, papilla, minor/major calyces, renal pelvis and ureter. The physical specimen provides a direct gross-anatomy comparison.
Original teaching slide50(H&E): renal corpuscles distinguish cortex, medullary pyramids and papilla, cortical labyrinth and medullary rays. Used for anatomical identification, not a clinical diagnostic claim.
Journal of Neuroscience24(2004),10353–10363; DOI10.1523/JNEUROSCI.3228-04.2004. Abstract and Figure7: female-rat median-eminence explants incubated30min with/without500micromolar L-arginine; immunogold electron microscopy of GnRH terminals and pericapillary space. Culture experiments implicate endothelial nitric oxide in glial remodeling. Original indexed full text pmc.ncbi.nlm.nih.gov/articles/PMC6730291/ inspected; direct PMC CAPTCHA.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact