Empirical likelihood places probability masses on observed or data-supported values and maximizes their product subject to normalization and any estimating constraints.
For independent event times with survivor function , an exact event at contributes mass , a right-censored observation at contributes , and an interval-censored observation contributes . Multiplying these factors gives the event-time likelihood when the observation mechanism is noninformative. Maximizing over nonincreasing right-continuous survivor functions gives a nonparametric maximum-likelihood estimator rather than requiring a parametric density.
Partition the time axis into cells on which membership in each observed exact-event or censoring set is constant. Let be a cell's probability mass and indicate whether cell is permitted by observation . The empirical likelihood has the displayed form, with nonnegative masses summing to one. Columns of that agree can be combined. If column is componentwise dominated by another column , moving all mass from to cannot reduce any factor, so an unconstrained nonparametric maximum-likelihood estimator can omit column . The remaining log-likelihood is a concave function of the masses. Extra constraints can prevent a domination move; for a fixed survivor function value, split cells at the constrained time and retain the associated linear mass constraint.
Suppose three exact event times coexist with a right-censored time and an interval , ordered as . Set and . Monotonicity bounds the three event masses by , and , while . Thus the mixed-censoring likelihood is bounded by the displayed expression. Equality is attained by putting all mass at . The reduced log-likelihood is strictly concave for , and its stationary equations yield , . The fitted masses are , , .
Articles by others on the same topic
There are currently no matching articles.