Mark A. Knepper is a researcher in kidney physiology who uses systems biology to investigate the regulation of water transport. A central example is how vasopressin changes the distribution of aquaporin-2 between the plasma membrane and the interior of collecting duct cells. His 2010 research report describes combining mass spectrometry, measurements of gene expression, mathematical modeling and physiological experiments to investigate this regulation.[ref]
Solute And Water Transport In Renal Epithelia by Mark A. Knepper. NIH RePORTER project 1ZIAHL001285-24, fiscal year 2010; Abstract
The timing gives the mechanism its interest. On a scale of seconds to minutes, membrane trafficking can move existing aquaporin-2 into the plasma membrane, changing the route available for water movement. That is a different regulatory step from making additional aquaporin-2 through altered gene expression. Measuring how much channel protein exists and where it is located therefore answers different questions.[ref]
Solute And Water Transport In Renal Epithelia by Mark A. Knepper. Abstract: rapid redistribution between membrane and cytoplasm
Mark A. Knepper also wrote a scientific remembrance of Maurice B. Burg, explaining how experiments on isolated renal tubules opened individual transport mechanisms to direct investigation.[ref]
Maurice B. Burg (1931–2022), discoverer of kidney transport mechanisms by Mark A. Knepper. Opening and discussion of the isolated-perfused-tubule method; PNAS 119, e2209749119, 2022
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