The Mayer–Vietoris sequence is a long exact homology sequence for a space decomposed into two suitable subspaces.
Identifying two distinct points of produces a space with homology groups and all higher groups zero. Cover the identified point by the image of two small disks, a contractible wedge of disks, and take as the other open set the complement of the point, a cylinder. Their intersection is two annuli. In the Mayer–Vietoris sequence, of this intersection maps onto of the cylinder with a rank-one kernel, producing . The kernel at has rank one and produces .
Attach two disks to a simply connected space along disjoint null-homotopic boundary circles, and additionally identify one interior point of each disk. Assume the attachments are CW complexes or admit compatible triangulations. The extra interior identification contributes a copy of to the first homology group, in addition to the two new second-homology classes. Indeed, after the first attachment , the intersection with has two components, . In the Mayer–Vietoris sequence, the map sends to , whose kernel is . If , exactness gives . The degree-two sequence is , which splits because is free. For , the integral homology groups are in degrees zero through three.
If a space is a union of subcomplexes and every nonempty intersection is acyclic, its homology vanishes in degrees at least . Induction with the Mayer–Vietoris sequence proves the bound; the boundary of an -simplex covered by its facets shows sharpness.

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The Mayer–Vietoris sequence is a fundamental tool in algebraic topology, particularly in the study of singular homology and cohomology theories. It provides a way to compute the homology or cohomology of a topological space from that of simpler subspaces.