A ligand-regulated protein family whose members often act as DNA-binding regulators of transcription. Subcellular distribution and activation mechanisms vary between members.
A nuclear receptor responding to glucocorticoid ligands, with regulated localization and recruitment of transcriptional partners.
Ligand-dependent regulation changes nuclear activity and interaction with DNA-associated factors. Because the receptor directly connects a small-molecule hormone to gene regulation, its response can include delayed changes requiring transcription and protein synthesis. [ref]

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  1. Intracellular receptor
  2. Receptor (biochemistry)
  3. Protein
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