The energy needed to remove specified nucleons from a bound atomic nucleus in its ground state. It compares neighboring nuclear masses, and so can reveal a nuclear shell closure more clearly than a smoothly varying total nuclear binding energy.
With bare nuclear masses, the proton separation energy is the energy needed to remove a proton. A negative value means the daughter plus proton has lower rest energy. Proton emission can still have a finite lifetime because of a Coulomb or centrifugal barrier.
A nuclear drip line marks a boundary beyond which one- or few-nucleon emission becomes energetically allowed. One- and two-particle nuclear separation energies can give distinct boundaries because of nuclear pairing.
The neutron drip line is the neutron-rich boundary at which one- or two-neutron emission becomes energetically possible. Neutrons beyond that boundary are not stably bound; the absence of a Coulomb barrier often makes their emission prompt, subject to angular-momentum barriers.
The proton drip line is the proton-rich boundary at which one- or two-proton emission becomes energetically possible. It is governed by proton separation energies, rather than the energetics of beta decay alone.
Writing positive nuclear binding energy as and nuclear mass as ,
The two-neutron nuclear separation energy is . In an independent-particle example, let the last occupied energy level have and the next empty level , for a chosen positive energy unit . With an unchanged core and no residual interactions, removal from the filled level costs , whereas removing the first particle added above it costs : the drop equals the one-particle gap. These are invented model inputs, not measured nuclear values. Nuclear pairing, rearrangement of the nuclear mean field, and correlations complicate that identification in real masses; a finite difference of nuclear binding energies is not automatically a bare one-particle gap.

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